Integrin α6 Antibody #3750
- WB
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 150, 125 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Integrin α6 is a 120 kDa protein with two splice variants, integrin α6, 6A and 6B (3), which function as receptors for laminins on the basal membrane to mediate cellular adhesion events (4-6). α6 integrins have been shown to play an important role in hematopoietic stem and progenitor cell homing to the bone marrow.
- Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71.
- Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100.
- Hogervorst, F. et al. (1993) J Cell Biol 121, 179-91.
- Sonnenberg, A. et al. (1990) J Cell Biol 110, 2145-55.
- Sonnenberg, A. et al. (1993) J Cell Sci 106 ( Pt 4), 1083-102.
- Shaw, L.M. et al. (1990) J Cell Biol 110, 2167-74.
Alternate Names
alpha6a; alpha6b; alpha6p; CD49f; ITGA6; VLA6
Limited Uses
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