Render Target: SSR
Render Timestamp:
11/4/2026, 11:26:47 AM EST
11/4/2026, 4:26:47 PM UTC
Commit: 6bb8e03c04ff513ea8e7325ce35abd2ab0759b0e
XML generation date: 2026-10-19 14:21:26.395
Product last modified at: 2026-10-20T07:01:19.719Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
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Phospho-PERK (Thr980) (16F8) Rabbit Monoclonal Antibody #3179

Filter:
  • WB

    Product Specifications

    REACTIVITY R
    SENSITIVITY Endogenous
    MW (kDa) 170
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Phospho-PERK (Thr980) (16F8) Rabbit Monoclonal Antibody detects endogenous levels of PERK phosphorylated at Thr980.

    Species Reactivity:

    Rat

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr980 of mouse PERK.

    Background

    Protein kinase-like endoplasmic reticulum kinase (PERK) is an eIF2α kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition (1-3). ER stress increases the activity of PERK, which then phosphorylates eIF2α to promote reduced translation. Research studies have demonstrated that PERK-deficient mice have defects in pancreatic β cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress (4). PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain (1-3). Phosphorylation of PERK at Thr980 serves as a marker for its activation status.

    Alternate Names

    AI427929; E2AK3; Eif2ak3; eukaryotic translation initiation factor 2 alpha kinase 3; Eukaryotic translation initiation factor 2-alpha kinase 3; Pancreatic eIF2-alpha kinase; Pek; Perk; PRKR-like endoplasmic reticulum kinase

    For Research Use Only. Not for Use in Diagnostic Procedures.
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