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Biomolecular Condensate Markers

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SPOP/DAXX Body DNA Repair Nuclear Speckles DNA Replication (OCCM Complex) Transcription Focus (Super Enhancer) Constitutive Heterochromatin SC-35/ SRSF2, SRRM2 Paraspeckles Cajal Body Facultative Heterochromatin (PcG Body) CYTOPLASM Nuclear Pore Processing Body (P-Body) Stress Granule NUCLEUS PML Body Nucleolus UBAP2L (E5X4E) Rabbit mAb TIA-1, TIAR, FMRP/FMR1, G3BP1 (E9G1M) XP® Rabbit mAb #61559 SPOP, Daxx (25C12) Rabbit mAb #4533 53BP1 (E7N5D) XP® Rabbit mAb #88439 MED1, BRD4 (E4X7E) Mouse mAb #63759 CBX2, RING1B (D22F2) XP® Rabbit mAb #5694 PML (E6S9L) Rabbit mAb #69789 MECP2, HP1α Antibody #2616 ORC, CDC6, CDT1 (D10F11) Rabbit mAb #8064 NPM, Nucleolin, Fibrillarin (C13C3) Rabbit mAb #2639 NONO, SFPQ, PSPC1 (E7L8B) Rabbit mAb #65992 Coilin (D2L3J) XP® Rabbit mAb #14168 NUP98 (C39A3) Rabbit mAb #2598 DCP1a, DCP2, EDC3, DDX6, EDC4/Ge-1 Antibody #2548 Targets above in bold text are shown in the accompanying data

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Biomolecular condensates, or membraneless organelles (MLOs), are involved in a myriad of cellular processes. MLOs are characterized by compartmentalization and concentration of proteins and nucleic acids, but without a lipid membrane. MLOs function across numerous cellular pathways, such as transcription and translation, DNA damage response, organelle biogenesis, and signal transduction; as such, they are highly varied in composition. This provides new opportunities for deeper study; these markers allow researchers to study MLOs and their dynamics in more detail, and simultaneously enable researchers to determine if other proteins of interest function in these MLOs. As these MLOs and their components are still being identified and characterized, presented here are routinely used markers for MLOs and antibodies available from CST for their study.