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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SELENBP1 (F7V8F) Rabbit mAb #99613

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  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 52
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SELENBP1 (F7V8F) Rabbit mAb recognizes endogenous levels of total SELENBP1 protein.

    Species Reactivity:

    Human, Mouse, Rat

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Rabbit

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro15 of human SELENBP1 protein.

    Background

    Selenium-binding protein 1 (SELENBP1), also known as SBP, is a widely expressed methanethiol oxidase, an enzyme capable of converting methanethiol to hydrogen sulfide, hydrogen peroxide, and formaldehyde (1). SELENBP1 is able to bind selenium, though it is not required for its enzymatic activity; copper, however, is a required cofactor (2). SELENBP1 is reported to act as a tumor suppressor; its expression is downregulated in several types of cancer, such as lung, bladder, and colorectal cancer (3-5). SELENBP1 overexpression is associated with schizophrenia. The prefrontal cortex and blood of schizophrenia patients show elevated SELENBP1 gene expression levels, and transgenic mice engineered to express human SELENBP1 in the frontal cortex exhibit a subset of schizophrenia-like phenotypes (6,7).
    For Research Use Only. Not for Use in Diagnostic Procedures.
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