Phospho-SHP-1 (Ser591) (F3Y8A) Rabbit Monoclonal Antibody #62825
- WB
- IP
Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 68 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
SHP-1 can be phosphorylated by PKC at its C-terminal Ser591. The phosphorylation at Ser591 inhibits SHP-1 phosphatase activity (7).
- Yi, T.L. et al. (1992) Mol Cell Biol 12, 836-46.
- Yi, T. et al. (1995) Blood 85, 87-95.
- Keilhack, H. et al. (2001) J Cell Biol 152, 325-34.
- Yi, T. et al. (1993) Mol Cell Biol 13, 7577-86.
- Wu, C. et al. (2003) Gene 306, 1-12.
- Bhattacharya, R. et al. (2008) J Mol Signal 3, 8.
- Jones, M.L. et al. (2004) J Biol Chem 279, 40475-83.
Alternate Names
HCP; HCPH; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; HPTP1C; protein tyrosine phosphatase non-receptor type 6; protein tyrosine phosphatase, non-receptor type 6; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; PTP-1C; PTP1C; PTPN6; SH-PTP1; SHP-1; SHP-1L; SHP1; Tyrosine-protein phosphatase non-receptor type 6
Limited Uses
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