Phospho-ATP-Citrate Lyase (Ser455) (F4T8R) Rabbit mAb #97366
- WB
- IP
- IHC
- F
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 125 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IHC-Immunohistochemistry
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
| Immunohistochemistry (Paraffin) | 1:400 - 1:1600 |
| Flow Cytometry (Fixed/Permeabilized) | 1:400 - 1:1600 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
ATP-citrate lyase is also critical in the pathogenesis of Parkinson’s disease (PD). α-synuclein mutations activate ATP-citrate lyase, leading to elevated cytoplasmic p300 activity. Hyperactivation of cytoplasmic p300 subsequently promotes mTORC1 signaling to inhibit autophagy, causing the aggregation of α-synuclein (6).
- Towle, H.C. et al. (1997) Annu Rev Nutr 17, 405-33.
- Potapova, I.A. et al. (2000) Biochemistry 39, 1169-79.
- Hughes, K. et al. (1992) Biochem J 288 ( Pt 1), 309-14.
- Pierce, M.W. et al. (1982) J Biol Chem 257, 10681-6.
- Berwick, D.C. et al. (2002) J Biol Chem 277, 33895-900.
- Son, S.M. et al. (2025) Neuron, 1908-1924.e13. doi: 10.1016/j.neuron.2025.03.028.
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