Cell Signaling Technology Logo
1% for the planet logo
Trial Size Available Flag
Recombinant Flag
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

NLRP7 (F9U8L) Rabbit mAb #58464

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 112
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    NLRP7 (F9U8L) Rabbit mAb recognizes endogenous levels of total NLRP7 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu104 of human NLRP7 protein.

    Background

    NOD-like receptor (NLR) family pyrin domain containing 7 (NLRP7) is a cytoplasmic immune receptor protein that recognizes microbial lipopeptides (1). NLRP7 is expressed in primates, but rodents have no orthologous genes (2-4). NLRP7 is required for IL-1β release in response to Mycoplasma spp. infection, and is activated in response to infection with other types of Gram-positive bacteria (1). While the mechanism is not well understood, NLRP7 is also critical for placental development; mutations in maternal NLRP7 may result in hydatidiform mole, a type of abnormal pregnancy that results in spontaneous abortion, defective embryonic development, or reproductive wastage (5,6). Mutations in males, however, do not negatively impact reproductive outcomes (6). NLRP7 may also play a role in gut homeostasis, as a particular coding variant, p.S361L, is associated with increased risk of developing ulcerative colitis (7).
    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.