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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MAZ (F3I2I) Rabbit mAb #90940

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 55
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MAZ (F3I2I) Rabbit mAb recognizes endogenous levels of total MAZ protein. This antibody detects isoforms 1, 3, and 4 of MAZ protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MAZ protein.

    Background

    The Myc-associated zinc finger protein (MAZ) is a transcription factor (TF) with four annotated isoforms and is widely expressed in most human tissues. This protein was independently identified as a regulator of MYC gene expression (1), activator of an insulin promoter (2), and modulator of serum amyloid A (3). Previous studies have shown that MAZ plays important roles in regulation of a wide variety of genes (4-6). Specifically, MAZ plays a dual role in regulating transcription initiation and termination processes. More recently, genome-wide screens have identified MAZ as a requirement for CTCF-mediated insulation (7). MAZ has also been shown to be highly expressed in malignant tumors and to promote tumorigenesis by directly binding to target gene promoters and cooperating with other TFs (8-13). 
    For Research Use Only. Not For Use In Diagnostic Procedures.
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