Lyric/Metadherin (D5Y8R) XP® Rabbit mAb #14065
- WB
- IHC
Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 65,75 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:150 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Differential subcellular localization and overexpression of Lyric/AEG-1/MTDH has been seen in multiple human cancers. Lyric/AEG-1/MTDH is involved in signaling pathways related to various cellular functions including proliferation and apoptosis/survival, and its alteration in cancer is associated with poor prognosis (reviewed in 2). In breast cancer, increased Lyric/AEG-1/MTDH may confer increased chemoresistance as well as metastasis (3,4). Lyric/AEG-1/MTDH expression is important in signaling and disease progression of hepatocellular carcinoma (HCC) (5) and glioblastoma multiforme (GBM) (6).
- Britt, D.E. et al. (2004) Exp Cell Res 300, 134-48.
- Hu, G. et al. (2009) Clin Cancer Res 15, 5615-20.
- Brown, D.M. and Ruoslahti, E. (2004) Cancer Cell 5, 365-74.
- Hu, G. et al. (2009) Cancer Cell 15, 9-20.
- Yoo, B.K. et al. (2009) J Clin Invest 119, 465-77.
- Emdad, L. et al. (2010) Mol Cancer Ther 9, 79-88.
Alternate Names
3D3; AEG-1; AEG1; LYRIC; Metadherin; Metastasis Adhesion Protein; MTDH
Limited Uses
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