LGALS3BP (F2K6Q) Rabbit mAb #38514
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 100, 75-80, 28 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Essentially, LGALS3BP-mediated integrin activation triggers intracellular signaling pathways, including the Akt, JNK, and Ras-ERK cascades. These pathways are essential for cell proliferation and survival. Essentially, LGALS3BP can activate signaling pathways that promote cell growth. Not surprisingly, therefore, LGALS3BP is overexpressed in certain pathological conditions, notably in various cancers, including pancreatic, lung, and breast cancers, hepatocellular carcinoma, and other tumor types. (3-6). Overexpression is associated with tumor progression, metastasis, and poor prognosis (5). It plays a role in other disease conditions, such as hepatic fibrosis, where it influences TGF-β1 signaling and availability, viral infections, such as HIV, and autoimmune diseases, such as systemic lupus erythematosus (2-7).
LGALS3BP is a multifaceted protein with significant roles in cell biology and disease. Its involvement in cancer progression and other pathological conditions makes it an area of active research, and overexpression in tumors makes it a promising target for diagnostic antibodies and drug development (4,8,9).
- White, M.J. et al. (2015) J Immunol 195, 1858-67.
- Zhang, X. et al. (2019) Cell Signal 63, 109359.
- Xu, G. et al. (2019) PLoS Pathog 15, e1008002.
- Capone, E. et al. (2021) J Transl Med 19, 405.
- Kim, D.H. et al. (2024) Cancer Commun (Lond) 44, 1106-1129.
- El Bannoudi, H. et al. (2023) Arthritis Rheumatol 75, 711-722.
- Choi, Y.S. et al. (2022) Proc Natl Acad Sci U S A 119, e2119048119.
- Li, L. et al. (2024) Aging (Albany NY) 16, 4033-4051.
- Dufrusine, B. et al. (2023) Mol Oncol 17, 1460-1473.
Limited Uses
Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.
Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.