IL4R (F6C4Z) Rabbit mAb (BSA and Azide Free) #37775
- WB
- F
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 75-80, 120 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- F-Flow Cytometry
Species Cross-Reactivity Key:
- M-Mouse
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.
Formulation
For standard formulation of this product see product #56538
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
IL4R is a transmembrane ligand binding protein composed of a heterodimer alpha and gamma receptor complex (4,5). IL4R has been shown to bind both IL-4 and interleukin-13 (IL-13), regulating immunoglobulin E (IgE) and chemokine production during allergic inflammation (6). In addition to its role in regulating immune response, signaling through IL4R is also implicated in diseases such as asthma, allergy, and cancer, making it a potent target for various therapies (7-9). Increased IL4R expression has been observed in tumors (9,10), and several mutations in IL4R are associated with metastatic cancers, underscoring its importance in cancer progression and as a target for chemotherapy development (10,11).
- Yokota, T. et al. (1986) Proc Natl Acad Sci U S A 83, 5894-8.
- Grabstein, K. et al. (1986) J Exp Med 163, 1405-14.
- Hou, J. et al. (1994) Science 265, 1701-6.
- Keegan, A.D. et al. (1994) Cell 76, 811-20.
- Naz, S. et al. (2019) Int J Biol Macromol 123, 239-245.
- Reece, P. et al. (2014) PLoS One 9, e100734.
- Massoud, A.H. et al. (2016) Nat Med 22, 1013-22.
- Aranda, C.J. et al. (2023) Allergy 78, 752-766.
- Viganò, E. et al. (2018) Blood 131, 2036-2046.
- Bankaitis, K.V. and Fingleton, B. (2015) Clin Exp Metastasis 32, 847-56.
- de Groot, A.E. et al. (2022) Neoplasia 32, 100830.
Limited Uses
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