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  1. Products /
  2. Primary Antibodies /
  3. COLEC11 (E9F9S) Rabbit mAb
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Recombinant Flag
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

COLEC11 (E9F9S) Rabbit mAb #85090

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 35, 28
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    COLEC11 (E9F9S) Rabbit mAb recognizes endogenous levels of total COLEC11 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu132 of human COLEC11 protein.

    Background

    Collectin-11 (COLEC11), also known as collectin kidney protein 1 (CL-K1), is a soluble pattern-recognition lectin and member of the collectin family (1). Collectins are composed of a collagen-like region and a C-terminal carbohydrate-recognition domain (CRD) (2). During embryogenesis, COLEC11 is highly expressed in craniofacial cartilage, heart, bronchi, kidney, and vertebral bodies. It may act as a guidance cue for neural crest cell migration via recognising specific carbohydrate epitopes (3). COLEC11 is secreted in the plasma and can bind a wide range of ligands, including pathogen-associated molecular patterns (PAMPs), like lipopolysaccharide (LPS) and lipoteichoic acid (LTA) (4). After binding a PAMP, COLEC11 can activate mannan-binding lectin (MBL)-associated serine proteases (MASP1, MASP2, and MASP3) to initiate complement activation and subsequent immune processes (5,6). COLEC11 has also been shown to upregulate IL-10, but downregulate IL-6 production in retinal pigment epithelial cells (RPE) and regulate antigen-presenting cell (APC) activation in a mouse model of collagen-induced rheumatoid arthritis (7,8). Elevated COLEC11 levels in the plasma are associated with the clotting disease disseminated intravascular coagulation and often lead to organ failure (9). COLEC11 has recently been identified as a tumor growth-promoting protein by directly stimulating cancer cell proliferation and by promoting a more immunosuppressive tumor microenvironment (TME). It is therefore a possible therapeutic target (10).   

    Database Links

    UniProt ID: Q9BWP8


    Entrez-Gene Id: 78989


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