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  1. Products /
  2. Primary Antibodies /
  3. CHMP7 (F4P9J) Rabbit mAb
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Recombinant Flag
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CHMP7 (F4P9J) Rabbit mAb #43781

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  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 61
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CHMP7 (F4P9J) Rabbit mAb recognizes endogenous levels of total CHMP7 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro402 of human CHMP7 protein.

    Background

    Charged multivesicular body protein 7 (CHMP7) is a part of the endosomal sorting complex required for transport-III (ESCRT-III) (1,2). CHMP7 is typically found in the cytoplasm under homeostatic conditions, but it continually diffuses into the nucleus (1,2). To prevent accumulation, it is then actively exported back to the cytoplasm by exportin-1 (1,2). Upon completion of mitosis, CHMP7 helps to reform the nuclear envelope (3). CHMP7 can also regulate interactions between the endoplasmic reticulum and mitochondria (3). Micronuclei, often present in cancer cells with chromosomal instability, can be disrupted by CHMP7 accumulation and oligomerization, which occurs with increased intracellular reactive oxygen species (4). CHMP7 is also involved in amyotrophic lateral sclerosis (ALS) and may be a therapeutic target. Aberrant CHMP7 nuclear accumulation in neurons leads to nuclear pore damage and TDP-43 dysfunction (2,5).

    Database Links

    UniProt ID: Q8WUX9


    Entrez-Gene Id: 91782


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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