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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CD180/RP105 (E5D4P) Rabbit mAb #53126

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 98
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CD180/RP105 (E5D4P) Rabbit mAb recognizes endogenous levels of total CD180/RP105 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domain of human CD180/RP105 protein.

    Background

    CD180/RP105 is a type-I transmembrane glycoprotein that is restricted to expression in mature B cells. Research studies have shown that CD180 engages signaling cascades in mature B cells that drive cell proliferation (1-3). Indeed, CD180 functions with TLR4 as an LPS receptor on B cells and, upon binding LPS, transmits proliferation and survival signals that require the Vav family of guanine nucleotide exchange factors (4-6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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