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ANT1/SLC25A4 Antibody

ANT1/SLC25A4 Antibody #69569

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Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	28
SOURCE	Rabbit

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

ANT1/SLC25A4 Antibody recognizes endogenous levels of total ANT1/SLC25A4 protein. This antibody does not cross-react with ANT2/SLC25A5 protein.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala150 of human ANT1/SLC25A4 protein. Antibodies are purified by peptide affinity chromatography.

Background

Adenine nucleotide translocators (ANTs) are a family of mitochondrial proteins that exchange ATP and ADP across the mitochondrial inner membrane. ANT1, also known as solute carrier family 25 member 4 (SLC25A4), is the isoform predominantly expressed in heart, muscle, and brain (1,2). Homozygous loss-of-function mutations in ANT1/SLC25A4 causes cardiomyopathy (2,3). In addition, ANT1/SLC25A4 is shown to be required for mitophagy (3). Furthermore, research studies show that ANT1/SLC25A4 facilitates mitochondrial permeability transition induced by bile acids and, therefore, pyroptosis (4). ANT1/SLC25A4 may mediate the release of ATP from mitochondria to the cytoplasm in this process, which is critical for pyroptosome assembly (4).

Alternate Names

AAC1; Adenine nucleotide translocator 1; adenine nucleotide translocator 1 (skeletal muscle); adenine nucleotide translocator), member 4; ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; ADP/ATP translocase 1; ADT1; ANT; ANT 1; ANT1; heart/skeletal muscle ATP/ADP translocator; MTDPS12; MTDPS12A; PEO2; PEO3; PEOA2; SLC25A4; solute carrier family 25 (mitochondrial carrier; Solute carrier family 25 member 4; T1

Database Links

UniProt ID: P12235

Entrez-Gene Id: 291

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