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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Proglucagon (D16G10) XP® Rabbit mAb #8233

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  • IHC
  • IF

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • IHC-Immunohistochemistry 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Immunohistochemistry (Paraffin) 1:400
    Immunofluorescence (Frozen) 1:400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    For a carrier free (BSA and azide free) version of this product see product #29302.

    Protocol

    Specificity / Sensitivity

    Proglucagon (D16G10) XP® Rabbit mAb recognizes endogenous levels of total proglucagon protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala137 of human proglucagon protein.

    Background

    Glucose homeostasis is regulated by a variety of hormones including glucagon. Glucagon is synthesized as the precursor molecule proglucagon and is proteolytically processed to yield the mature peptide in α cells of the pancreatic islets. Glucagon causes the release of glucose from glycogen and stimulates gluconeogenesis in the liver (1,2).

    Alternate Names

    GCG; Glicentin; Glicentin-related polypeptide; GLP; GLUC; Glucagon; Glucagon-like peptide 1; GRPP; OXM; OXY; Oxyntomodulin

    For Research Use Only. Not for Use in Diagnostic Procedures.
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